Okilactomycin, a novel antibiotic produced by a Streptomyces species. II. Structure determination.
نویسندگان
چکیده
Structure of a novel antibiotic, okilactomycin, was determined by a combination of spectroscopic and X-ray crystallographic studies. Okilactomycin has a unique structure containing 13-membered ring cyclized by carbon-carbon bond.
منابع مشابه
Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. II. Physico-chemical properties and structure determination.
The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a Streptomyces sp. RSP9. The structure of radamycin was elucidated by NMR, LC-MS and FAB-MS and was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids.
متن کاملDC-52, a novel antitumor antibiotic. 2. Isolation, physico-chemical characteristics and structure determination.
DC-52, C18H22N2O4, is a new antitumor antibiotic produced by Streptomyces melanovinaceus nov. sp. The structure of DC-52 has been determined by consideration of spectral data. It has the novel skeleton, 8,11-iminoazepinoisoquinoline.
متن کاملCV-1, a new antibiotic produced by a strain of Streptomyces sp. II. structure determination.
The structure of a new antibiotic, CV-1 was determined to be 1,2-diamino-1,2-N,N'-carbonyl-1,2-dideoxy-alpha-D-glucose hydrate by spectral and chemical studies. CV-1 possessed a unique open ring hemiaminal structure. CV-1 synthesized from N-carbamoyl-D-glucosamine was identical to material isolated from fermentation.
متن کاملIsolation and Identification of Streptomyces ramulosus from Soil and Determination of Antimicrobial Property of its Pigment
Background and objective: Pigment production by microorganisms is important due to more rapid growth, higher efficiency, easier extraction, and antimicrobial effects compared to other methods. The aim of the present study is to isolate and identify antibiotic pigment-producing actinomycetes from the soil of the Persian Gulf and to evaluate the antibiotic activity of their pigments in the second...
متن کاملNisamycin, a new manumycin group antibiotic from Streptomyces sp. K106. II. Structure determination and structure-activity relationships.
Nisamycin, a novel manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. Structural elucidation of nisamycin was achieved by detailed NMR spectral analyses and comparison of the NMR data of nisamycin with those of other manumycin group antibiotics. The structure was confirmed by chromic acid oxidation. The absolute stereochemistry of nisamycin was determined ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of antibiotics
دوره 40 11 شماره
صفحات -
تاریخ انتشار 1987